George C. Engelmayr, Jr.
Assistant Professor
223 Hallowell Building
University Park, PA 16802
Phone:814-865-8088 / Fax: 814-863-0490
E-mail: gce101@psu.edu
Personal Website: http://www.bioe.psu.edu/labs/Engelmayr-Lab/index.htm
Education
Ph.D. Bioengineering, 2005
University of Pittsburgh
Research Interests
The over-arching goal of research in the Engelmayr Lab is to contribute toward the development of functional engineered tissues for basic science and regenerative medicine applications.
Aspects of our interdisciplinary work include tissue-specific scaffold design and fabrication for promoting the development of biomimetic tissue properties, bioreactor design and use in studying biophysical and biochemical regulation of engineered tissue formation and stem cell differentiation, and mathematical modeling to integrate the fruit of experimentation into a cohesive predictive framework.
Among other tissue applications, projects in our lab focus on tissue engineering in the heart, including vessels, valves, and myocardium.
Selected Publications
Engelmayr, G. C., Jr., M. Cheng, C. J. Bettinger, J. T. Borenstein, R. Langer, and L. E. Freed. “Accordion-like honeycombs for tissue engineering of cardiac anisotropy.” Nature Materials. 2008 Dec; 7(12):1003-10 Engelmayr, G. C., Jr., L. Soletti, S. C. Vigmostad, S. G. Budilarto, W. J. Federspiel, D. A. Vorp and M. S. Sacks. "A novel flex-stretch-flow bioreactor for the study of engneered heart valve tissue mechanobiology." Ann Biomed Eng. 2008 May; 36(5): 700-12. Engelmayr, G. C., Jr. and M. S. Sacks. "Prediction of extracellular matrix stiffness in engineered heart valve tissues based on nonwoven scaffolds." Biomech Model Mechanobiol. 2008 Aug; 7(4): 309-21. Engelmayr, G. C., Jr., V. L. Sales, J. E. Mayer, Jr. and M. S. Sacks. "Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart valve tissues." Biomaterials. 2006 Dec; 27(36): 6083-95. Engelmayr, G. C., Jr. and M. S. Sacks. "A structural model for the flexural mechanics of nonwoven tissue engineering scaffolds." J Biomech Eng. 2006 Aug; 128(4): 610-22. Engelmayr, G. C., Jr., G. D. Papworth, S. C. Watkins, J. E. Mayer, Jr. and M. S. Sacks. "Guidance of engineered tissue collagen orientation by large-scale scaffold microstructures." J Biomech. 2006; 39(10): 1819-31. Engelmayr, G. C., Jr., E. Rabkin, F. W. Sutherland, F. J. Schoen, J. E. Mayer, Jr. and M. S. Sacks. "The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue." Biomaterials. 2005 Jan; 26(2): 175-87. Engelmayr, G. C., Jr., D. K. Hildebrand, F. W. Sutherland, J. E. Mayer, Jr. and M. S. Sacks. "A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials." Biomaterials. 2003 Jun; 24(14): 2523-32 |
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