Keefe Manning
Assistant Professor
219 Hallowell Building
University Park, PA 16802
Phone: 814-863-6318 / Fax:814-863-0490
E-mail: kbm10@psu.edu
Personal Website: http://www.bioe.psu.edu/labs/Manning-Lab/index.html
Education
Ph.D. Biomedical Engineering, Virginia Commonwealth University, 2001
Research Interests
Dr. Manning’s research approach focuses primarily on 1) understanding the native cardiovascular system fluid mechanics, 2) understanding the diseased cardiovascular system fluid mechanics, and 3) the impact that cardiovascular prosthetics generate during and post implantation. To accomplish these goals, in vitro experiments are implemented to understand the cardiovascular system, and to investigate and improve cardiovascular prosthetics, artificial hearts, blood pumps, and mechanical heart valves including efforts to minimize the impact of these devices to the cardiovascular system. The research is conducted in the Artificial Heart Laboratory and the Cardiovascular Fluid Dynamics Laboratory. The in vitro experiments are compared with in vivo data collected at the Hershey Medical Center and the Aarhus University Hospital in Denmark.
Specifically, in vitro experiments are conducted utilizing state-of-the-art flow measurement techniques such as high speed videography, three-component laser Doppler velocimetry (LDV), and particle image velocimetry (PIV). By employing these techniques, flow phenomena (turbulence, eddys, stagnant zones, recirculation regions, vortices) can be quantified and the devices improved to minimize blood damage (hemolysis) and eliminate thrombus deposition and formation.
Since more left ventricular assist devices (LVADs) are being implanted as bridge to recovery and bridge to transplant, further research interests include improving the surgical implantation of these LVADs to minimize blood trauma associated with implantation and eliminate any potential for thromboembolic events caused by the LVAD end-to-side anastomsis. Other research efforts include investigating the influence of the Non-Newtonian behavior of blood in connection with the Penn State pediatric ventricular assist device (PVAD) currently in development, and conducting blood rheological studies to better understand the flow mechanisms that induce thrombus development and deposition associated with cardiovascular prosthetics.
Selected Publications
Medvitz RB, Kreider JW, Manning KB, Fontaine AA, Deutsch S, Paterson EG.Development and validation of a computational fluid dynamics methodology for simulation of pulsatile left ventricular assist devices.ASAIO J. 2007 Mar-Apr;53(2):122-31.
Kreider JW, Manning KB, Oley LA, Fontaine AA, Deutsch S. The 50cc Penn State left ventricular assist device: a parametric study of valve orientation flow dynamics. ASAIO J. 2006 Mar-Apr;52(2):123-31.
Herbertson LH, Reddy V, Manning KB, Welz JP, Fontaine AA, Deutsch S.Wavelet transforms in the analysis of mechanical heart valve cavitation. J Biomech Eng. 2006 Apr;128(2):217-22.
Deutsch S, Tarbell JM, Manning KB, Rosenberg G, Fontaine AA. Experimental Fluid Mechanics of Pulsatile Artificial Blood Pumps. Ann Rev Fluid Mech 2006; 38:65-86. pdf
Long JA, Undar A, Manning KB, Deutsch S. Viscoelasticity of Pediatric Blood and its Implications for the Testing of a Pulsatile Pediatric Blood Pump. ASAIO J 2005; 51(5):563-566. pdf
Herbertson LH, Manning KB, Reddy V, Fontaine AA, Tarbell JM, Deutsch S. The effect of dissolved carbon dioxide on cavitation intensity in mechanical heart valves. J Heart Valve Dis. 2005 Nov;14(6):835-42.
Sohn K, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Acoustic and visual characteristics of cavitation induced by mechanical heart valves. J Heart Valve Dis 2005;14:551-558. pdf
Oley LA, Manning KB, Fontaine AA, Deutsch S. Off design considerations of the 50cc Penn State ventricular assist device. Artif Organs 2005;29:378-386. pdf
Manning KB, Przybysz TM, Fontaine AA, Tarbell JM, and Deutsch S. Near field flow characteristics of the Bjork-Shiley Monostrut valve in a modified single shot valve chamber. ASAIO J2005;51:133-138. pdf
Hochareon P, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Correlation of in vivo clot deposition with the flow characteristics in the 50cc Penn State Artificial Heart: a preliminary study. ASAIO J 2004;50:537-542. pdf
Hochareon P, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Wall shear-rate estimation within the 50cc Penn State Artificial Heart using particle image velocimetry. ASME J Biomech Eng 2004;126:430-437. pdf
Hochareon P, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Fluid dynamic analysis of the 50cc Penn State Artificial Heart under physiological operating conditions using particle image velocimetry. ASME J Biomech Eng. 2004; 126:585-593. pdf
Manning KB, Kini V, Fontaine AA, Deutsch S, and Tarbell JM. Regurgitant flow field characteristics of the St. Jude Bileaflet mechanical heart valve under physiologic pulsatile flow using particle image velocimetry. Artif Organs 2003;27:840-846. pdf
Hochareon P, Manning KB, Fontaine AA, Deutsch S, and Tarbell JM. Diaphragm motion affects flow patterns in an artificial heart. Artif Organs 2003;27:1102-1109. pdf
Johansen P, Manning KB, Tarbell JM, Fontaine AA, Deutsch S, and Nygaard H. A new method for evaluation of cavitation near mechanical heart valves. ASME J Biomech Eng 2003;125:663-670. pdf